1/6/2024 0 Comments Noni juiceOur results suggest that the presence of several biological active phytochemicals in noni juice enhances resistance to SARS-CoV-2 by interfering with its ability to bind ACE2. scopoletin, quercetin, rutin and kaempferol) are also involved. But the modest activity of the most abundant iridoid, deacetylasperulosidic acid, indicates that other phytochemicals ( i.e. The iridoids worked synergistically towards inhibiting spike protein binding when assayed together, improving activity by more than 22% above the expected level. Scandoside was the most active of the three iridoids evaluated, reducing average spike protein-ACE2 interaction by 79.25%. Noni juice inhibited binding by approximately 69%. SARS-CoV-2 spike-ACE2 interaction experiments were carried out to further investigate the antiviral properties of noni juice and its major iridoids. Morinda citrifolia (noni) fruit juice has antiviral activity that involves enhancement of immune system function. This disease is caused by a coronavirus, SARS-CoV-2, which requires the binding of its spike protein to angiotensin-converting enzyme 2 (ACE2) for infection of the host cell. COVID-19 is a global pandemic that has claimed millions of lives.
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